Meera, G. ; Ramesh, N. ; Brahmachari, Samir K. (1989) Zintrons in rat α-lactalbumin gene FEBS Letters, 251 (1-2). pp. 245-249. ISSN 0014-5793
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Official URL: http://dx.doi.org//10.1016/0014-5793(89)81463-2
Related URL: http://dx.doi.org/10.1016/0014-5793(89)81463-2
Abstract
The eukaryotic genome is characterised by the occurrence of a large amount of repetitive DNA which exists within and around coding sequences. Random repeats of (TG)n sequences have been observed in several introns. In this paper we show that (TG)14 and (TG)24 sequences present in the third intron of rat α-lactalbumin gene adopt left-handed Z-helices under varying superhelical densities. The overall sequence of the parent plasmid further influenced the level of supercoiling at which the B to Z transition could be induced in (TG)n sequences. Such Z-potential intervening sequences (zintrons) could act as buffers to maintain desired levels of supercoiling near the transcribed sequences.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Federation of European Biochemical Societies. |
| Keywords: | Lactalbumin; α-Intron sequence; DNA; Z-DNA Supercoiling; (Rat) |
| ID Code: | 6446 |
| Deposited On: | 20 Oct 2010 10:22 |
| Last Modified: | 16 May 2016 16:47 |
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