The interleukin-6 −174G/C promoter polymorphism is not associated with endometriosis in South Indian women

Abstract

Objective: To investigate the association of the −174 G/C promoter polymorphism of the interleukin-6 (IL-6) gene with endometriosis in South Indian women. Methods: The genotype frequencies of the common IL-6174 G/C polymorphism were compared in infertility patients with (n = 232) and without (n = 210) endometriosis using polymerase chain reaction (PCR) and sequencing analysis. Results: The genotype frequencies among the cases and controls were G/G 62.9% and 71.9%, G/C 34. 1% and 25.2%, and C/C 3.0% and 2.9%. The G and C allele frequencies were 80% and 84.6%, and 20% and 15.4%, respectively. There were no statistically signficant differences in the genotype distributions or allele frequencies between the cases and controls (P = .12). Conclusions: The present study demonstrates no signficant association between the IL-6 -174 G/C promoter polymorphism and endometriosis in South Indian women.