HIV-1 clade-C-associated "ALS"-like disorder: first report from India

Sinha, Sanjib ; Mathews, Thomas ; Arunodaya, G. R. ; Siddappa, Nagadenahalli B. ; Ranga, Udaykumar ; Desai, A. ; Ravi, V. ; Taly, A. B. (2004) HIV-1 clade-C-associated "ALS"-like disorder: first report from India Journal of the Neurological Sciences, 224 (1-2). pp. 97-100. ISSN 0022-510X

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.jns.2004.06.006

Abstract

A patient of ALS-like disorder in an HIV-1 clade-C-infected heterosexual male is being reported. A 37-year-old gentleman presented with subacute, progressive asymmetrical onset of weakness and wasting of upper limbs associated with brisk muscle stretch reflexes and without any sensory or sphincter involvement. While nerve conduction tests were normal, the EMG of proximal and distal limb muscles on both sides revealed evidence of denervation and reinnervation. Routine blood and urine tests and investigations for underlying causes of motor neuron disease were noncontributory. He was HIV-1, subtype clade C seropositive. A diagnosis of HIV-related anterior horn cell disease was considered and zidovudine, lamivudine and nevirapine were started. After 1 month, there was a subjective improvement of 10% and objective improvement in strength of muscles of proximal upper limb on both sides by one grade power on MRC scale. Reports of amyotrophic lateral sclerosis (ALS)-like illness in HIV are sparse. The reversibility of "ALS"-like features in this subgroup of patients might offer an insight into the pathogenesis of amyotrophic lateral sclerosis. This is a first report of ALS-like illness caused by subtype C of HIV-1 strain.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:HIV-1; Subtype-C; Motor Neuron Disease; Amyotrophic Lateral Sclerosis
ID Code:63659
Deposited On:29 Sep 2011 06:29
Last Modified:29 Sep 2011 06:29

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