Chandrasekhar, S. ; Venkat Reddy, M. (2000) Enantioselective total synthesis of the antihypertensive agent (S,R,R,R)-Nebivolol Tetrahedron, 56 (34). pp. 6339-6344. ISSN 0040-4020
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/S0040-4020(00)00572-X
Abstract
The total synthesis of (S,R,R,R)-Nebivolol, a hypertensive agent, is reported. Claisen rearrangement and a one-pot Sharpless asymmetric epoxidation, intramolecular epoxide opening with internal phenoxide anion to generate the chiral chromane are the key steps.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Amine; Chromanes; Antihypertensive; Epoxidation; Coupling Reaction |
| ID Code: | 63503 |
| Deposited On: | 29 Sep 2011 04:15 |
| Last Modified: | 29 Sep 2011 04:15 |
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