Sinha, Kanchan ; Bhatnagar, Rakesh (2010) GroEL provides protection against Bacillus anthracis infection in BALB/c mice Molecular Immunology, 48 (1-3). pp. 264-271. ISSN 0161-5890
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.molimm.2010.08.001
Abstract
Heat shock proteins (Hsps) of the HSP60 and HSP70 family are highly conserved and essential to all living organisms. Hsps are immunodominant in numerous microbial infections and have been investigated for their vaccine potential. We investigated the immunogenicity and protective efficacy of GroEL and DnaK of B. anthracis in murine model. Both Hsps were found to be highly immunogenic with mixed antibody response (both IgG1 and IgG2a), indicating stimulation of both humoral and cell-mediated immunity. Cytokine profile also confirmed robust T-cell response with increase in lymphocyte proliferation. Immunization with GroEL conferred 100% protection to mice against B. anthracis infection whereas DnaK couldn't provide protection.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Heat Shock Protein; Mixed Th1/Th2 Response; Protective Efficacy |
| ID Code: | 63382 |
| Deposited On: | 28 Sep 2011 10:31 |
| Last Modified: | 28 Sep 2011 10:31 |
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