Kamal, A. ; Satyanarayana, M. ; Devaiah, V. ; Rohini, V. ; Yadav, J. S. ; Mullick, B. ; Nagaraja, V. (2006) Synthesis and biological evaluation of coumarin linked fluoroquinolones, phthalimides and naphthalimides as potential DNA gyrase inhibitors Letters in Drug Design & Discovery, 3 (7). pp. 494-502. ISSN 1570-1808
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Official URL: http://www.ingentaconnect.com/content/ben/lddd/200...
Related URL: http://dx.doi.org/10.2174/157018006778194862
Abstract
A hybrid molecule synthesis strategy is employed to develop new molecules with potential antibacterial activity. Three types of coumarin-linked hybrids have been synthesized. The coumarin ring system has been linked to phthalimido, naphthalimido and quinolone moieties at 4-position through piperazino alkane spacers. These compounds have been evaluated for their antibacterial activity. Some of these new hybrids particularly phthalimido and naphthalimido ones have exhibited DNA gyrase inhibition activity.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Bentham Science Publishers. |
| Keywords: | Coumarins; Phthalimides; Naphthalimides and Fluoroquinolone DNA Gyrase Inhi |
| ID Code: | 63215 |
| Deposited On: | 28 Sep 2011 03:27 |
| Last Modified: | 28 Sep 2011 03:27 |
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