Yadav, Jhillu S. ; Rajender, Vemula (2010) Studies directed towards the total synthesis of (−)-dictyostatin European Journal of Organic Chemistry, 2010 (11). pp. 2148-2156. ISSN 1434-193X
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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/ejoc.20...
Related URL: http://dx.doi.org/10.1002/ejoc.200901448
Abstract
The stereoselective synthesis of the three major fragments (C1-C9, C10-C17, and C19-C26) of an antimitotic marine macrolide, (−)-dictyostatin, has been achieved with a desymmetrization strategy and Oppolzer syn and anti aldol protocols as the key reactions. Takai olefination and Sonogashira coupling reactions were successfully utilized to establish the 2Z,4E-dienoate portion of the C1-C9 fragment and Stille coupling for the Z-diene core of C19-C26.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons. |
| Keywords: | Aldol Reactions; Natural Products; Cross Coupling; Stereoselective Synthesis |
| ID Code: | 63155 |
| Deposited On: | 28 Sep 2011 03:48 |
| Last Modified: | 28 Sep 2011 03:48 |
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