Modular total synthesis of lamellarin G trimethyl ether

Yadav, Jhillu S. ; Uma Gayathri, Kamakolanu ; Subba Reddy, Basi V. ; Prasad, Attaluri R. (2009) Modular total synthesis of lamellarin G trimethyl ether Synlett, 2009 (1). pp. 43-46. ISSN 0936-5214

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Official URL: http://www.thieme-connect.com/ejournals/abstract/s...

Related URL: http://dx.doi.org/10.1055/s-0028-1087387

Abstract

A modular synthesis of the lamellarin G trimethyl ether has been developed based on the application of several reaction -sequences which include Friedel-Crafts acylation, esterification, haloarylation, and oxidative cyclization. The formation of pyrrolo [2,1-a]isoquinoline core, the key step for the successful completion of lamellarin G trimethyl ether synthesis, is comfortably accomplished through the haloarylation of 3-bromo-4-(3,4-dimethoxy-benzoyl)-6,7-dimethoxy-chroman-2-one which has resulted in exclusive endo product.

Item Type:Article
Source:Copyright of this article belongs to Thieme Medical Publishers.
Keywords:Lamellarins; Friedel-Crafts Acylation; Esterification; Bromoarylation; Oxidative Cyclization
ID Code:63128
Deposited On:28 Sep 2011 03:41
Last Modified:28 Sep 2011 03:41

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