Sabitha, Gowravaram ; Srinivas, Chitti ; Sudhakar, Kadari ; Rajkumar, Manne ; Maruthi, Chittapragada ; Yadav, Jhillu S. (2007) Enantioselective total synthesis of the antifungal agent (6S)-5,6-dihydro-6-[(2R)-2-hydroxy-6-phenylhexyl]-2H-pyran-2-one Synthesis, 2007 (24). pp. 3886-3890. ISSN 0039-7881
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Official URL: https://www.thieme-connect.com/ejournals/abstract/...
Related URL: http://dx.doi.org/10.1055/s-2007-990928
Abstract
An enantioselective route for the synthesis of (6S)-5,6-dihydro-6-[(2R)-2-hydroxy-6-phenylhexyl]-2H-pyran-2-one is reported. The synthesis is based on epoxide ring opening with a Grignard reagent and stereoselective reduction employing catecholborane as key reactions.
Item Type: | Article |
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Source: | Copyright of this article belongs to Thieme Medical Publishers. |
Keywords: | 6-substituted 5,6-dihydro-2H-pyran-2-ones; Catecholborane; Antifungal Activity |
ID Code: | 63068 |
Deposited On: | 28 Sep 2011 03:27 |
Last Modified: | 28 Sep 2011 03:27 |
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