Yadav, Jhillu S. ; Sreedhar, Pamu ; Srihari, Pabbaraja ; Dattatreya Sarma, Ganti ; Jagadeesh, Bharatam (2008) The concise synthesis of a key intermediate for the total synthesis of fumagillin, TNP-470, and ovalicin Synthesis, 2008 (9). pp. 1460-1466. ISSN 0039-7881
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Official URL: https://www.thieme-connect.com/ejournals/abstract/...
Related URL: http://dx.doi.org/10.1055/s-2008-1067030
Abstract
The facile synthesis of a key intermediate for the total synthesis of the antiangiogenic compound fumagillin, its semisynthetic analogue TNP-470, and ovalicin is described. The methodology employs a Diels-Alder strategy and a zinc-mediated ring-opening reaction to realize the cyclohexane backbone.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Thieme Medical Publishers. |
| Keywords: | Angiogenesis Inhibitors; Diels-Alder Reaction; Syn Reduction; Dihydroxylation; HIV |
| ID Code: | 63063 |
| Deposited On: | 28 Sep 2011 03:37 |
| Last Modified: | 28 Sep 2011 03:37 |
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