Bi(OTf)3 as mild, efficient and cost-effective catalyst for the alkylation of N-heterocycles with epoxides

Yadav, Jhillu S. ; Subbareddy, Basi V. ; Krishna, Awaru D. ; Reddy, Alluri R. ; Narasaiah, Akkirala V. (2008) Bi(OTf)3 as mild, efficient and cost-effective catalyst for the alkylation of N-heterocycles with epoxides Letters in Organic Chemistry, 5 (6). pp. 455-460. ISSN 1570-1786

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Abstract

Epoxides undergo smooth ring opening with N-heterocyclic compounds such as indoles and pyrroles in the presence of a catalytic amount of bismuth triflate under mild conditions to produce C-alkylated indole and pyrrole derivatives in high yields with a high regioselectivity. Imidazole and benzotriazole affords N-alkylated products under identical conditions.

Item Type:Article
Source:Copyright of this article belongs to Bentham Science Publishers.
Keywords:Epoxides; Bismuth Compounds; N-heterocycles; Tryptophol Derivatives
ID Code:62862
Deposited On:24 Sep 2011 04:56
Last Modified:24 Sep 2011 04:56

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