Yadav, J. S. ; Subba Reddy, B. V. ; Shubashree, S. ; Sadashiv, K. ; Naidu, Jaisree J. (2004) Ionic liquids-promoted multi-component reaction: Green approach for highly substituted 2-aminofuran derivatives Synthesis, 2004 (14). pp. 2376-2380. ISSN 0039-7881
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Official URL: http://www.thieme-connect.com/ejournals/abstract/s...
Related URL: http://dx.doi.org/10.1055/s-2004-831181
Abstract
The three-component coupling of aldehyde, dimethyl acetylenedicarboxylate (DMAD) and cyclohexyl isocyanide proceeds efficiently in [bmim]BF4 ionic medium under extremely mild conditions to afford the corresponding 2-aminofuran derivatives in high yields. The zwitterionic intermediate formed in situ from DMAD and isocyanide shows enhanced reactivity in ionic liquids, thereby reducing reaction times and improving the yields significantly. Ionic liquid helps to avoid the use of highly toxic and environmentally unfavorable benzene as solvent for this conversion. The recovered ionic liquid was reused for five to six times with consistent activity.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Thieme Medical Publishers. |
| Keywords: | Ionic Liquids (ILs); Multi-component Reaction; Furan Derivatives |
| ID Code: | 62830 |
| Deposited On: | 24 Sep 2011 04:48 |
| Last Modified: | 24 Sep 2011 04:48 |
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