Bismuth (III) triflate catalyzed condensation of isatin with indoles and pyrroles: a facile synthesis of 3,3-diindolyl-and 3,3-dipyrrolyl oxindoles

Yadav, Jhillu S. ; SubbaReddy, Basireddy V. ; Uma Gayathri, Kamakolanu ; Meraj, Syeda ; Prasad, Attaluri R. (2006) Bismuth (III) triflate catalyzed condensation of isatin with indoles and pyrroles: a facile synthesis of 3,3-diindolyl-and 3,3-dipyrrolyl oxindoles Synthesis, 2006 (24). pp. 4121-4123. ISSN 0039-7881

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Official URL: http://www.thieme-connect.com/ejournals/abstract/s...

Related URL: http://dx.doi.org/10.1055/s-2006-950373

Abstract

Indoles and pyrroles undergo a rapid condensation with isatin in the presence of 2 mol% of Bi(OTf)3, under mild reaction conditions, to afford the corresponding 3,3-di(3-indolyl)- and 3,3-di(2-pyrroryl)oxindoles in excellent yields and high regioselectivity. This method is ideal for the direct introduction of indoles and pyrroles onto an isatin moiety at the 3-position.

Item Type:Article
Source:Copyright of this article belongs to Thieme Medical Publishers.
Keywords:Bismuth; Bi(OTf)3; Oxindoles; 3,3-diindolyl Oxindoles; 3,3-dipyrrolyl Oxindoles
ID Code:62783
Deposited On:24 Sep 2011 04:51
Last Modified:24 Sep 2011 04:51

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