Patra, Ashis K. ; Bhowmick, Tuhin ; Ramakumar, Suryanarayanarao ; Chakravarty, Akhil R. (2007) Metal-based netropsin mimics showing at-selective DNA binding and DNA cleavage activity at red light Inorganic Chemistry, 46 (22). pp. 9030-9032. ISSN 0020-1669
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Official URL: http://pubs.acs.org/doi/abs/10.1021/ic701326z
Related URL: http://dx.doi.org/10.1021/ic701326z
Abstract
Copper(II) bis-arginate [Cu(l-arg)2](NO3)2 (1) and [Cu(l-arg)(phen)Cl]Cl (2) as mimics of the minor-groove-binding natural antibiotic netropsin show preferential binding to the AT-rich region of double-stranded DNA. The complexes with a d-d band near 600 nm display oxidative DNA cleavage activity on photoirradiation at UV-A light of 365 nm and at red light of 647.1 nm (Ar-Kr laser) in a metal-assisted photoexcitation process forming singlet oxygen (1O2) species in a type-2 pathway.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 6276 |
| Deposited On: | 20 Oct 2010 11:19 |
| Last Modified: | 24 May 2011 10:45 |
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