Sabitha, Gowravaram ; Nagendra Prasad, M. ; Yadav, J. S. (2011) TMSI-promoted diastereoselective synthesis of 5-(1'-hydroxy)-γ-butyrolactones Synthetic Communications, 41 (15). pp. 2290-2295. ISSN 0039-7911
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Official URL: http://www.tandfonline.com/doi/abs/10.1080/0039791...
Related URL: http://dx.doi.org/10.1080/00397911.2010.502985
Abstract
Trimethylsilyl iodide (TMSI) was found to be an efficient catalyst for the vinylogous Mukaiyama aldol reaction of 2-(trimethylsilyloxy)furan with various aldehydes with good diastereoselection. The reaction proceeds rapidly in CH2Cl2 affording the corresponding 5-(hydroxy(aryl)methyl)furan-2(5H)-ones in good yields. This method offers significant advantages such as efficiency, generality, and mild reaction conditions with shorter reaction time.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Taylor and Francis Group. |
| Keywords: | Aldehydes; Butyrolactones; Diastereoselection; TMSI; TMSOF |
| ID Code: | 62714 |
| Deposited On: | 24 Sep 2011 05:02 |
| Last Modified: | 24 Sep 2011 05:02 |
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