Emsley, Jonas ; White, Helen E. ; O'Hara, Bernard P. ; Oliva, Glaucius ; Srinivasan, Narayanaswamy ; Tickle, Ian J. ; Blundell, Tom L. ; Pepys, Mark B. ; Wood, Steve P. (1994) Structure of pentameric human serum amyloid P component Nature, 367 . pp. 338-345. ISSN 0028-0836
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Official URL: http://www.nature.com/nature/journal/v367/n6461/ab...
Related URL: http://dx.doi.org/10.1038/367338a0
Abstract
The three-dimensional structure of pentameric human serum amyloid P component at high resolution, the first reported for a pentraxin, reveals that the tertiary fold is remarkably similar to that of the legume lectins. Carboxylate and phosphate compounds bind directly to two calcium ions; interactions with a carboxyethylidene ring are mediated by Asn 59 and Gin 148 ligands of the calcium ions. These X-ray results indicate the probable modes of binding of the biologically important ligands, DNA and amyloid fibrils.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Nature Publishing Group. |
| ID Code: | 62638 |
| Deposited On: | 22 Sep 2011 02:40 |
| Last Modified: | 22 Sep 2011 02:40 |
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