Sastry, B. S. ; Suresh Babu, K. ; Hari Babu, T. ; Chandrasekhar, S. ; Srinivasa, P. V. ; Saxena, A. K. ; Madhusudana Rao, J. (2006) Synthesis and biological activity of amide derivatives of nimbolide Bioorganic & Medicinal Chemistry Letters, 16 (16). pp. 4391-4394. ISSN 0960-894X
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.bmcl.2006.05.105
Abstract
Nimbolide (1), a limonoid isolated from Azadirachta indica, is the chief cytotoxic principle in Neem leaves extract. Using nimbolide as a lead compound for anti-cancer analogue design, a series of nimbolide derivatives have been synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines. Out of 10 compounds screened 2g, 2h and 2i showed potent activity. Graphical abstract A series of nimbolide derivatives have been synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Azadirachta indica; Nimbolide Analogues; Anti-cancer Activity; Benzyl Amines |
| ID Code: | 62387 |
| Deposited On: | 22 Sep 2011 03:30 |
| Last Modified: | 22 Sep 2011 03:30 |
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