Total synthesis of azumamide E and sugar amino acid-containing analogue

Chandrasekhar, Srivari ; Lohitha Rao, Chennamaneni ; Seenaiah, Mallikanti ; Naresh, Police ; Jagadeesh, Bharatam ; Manjeera, Dharani ; Sarkar, Arpita ; Pal Bhadra, Manika (2009) Total synthesis of azumamide E and sugar amino acid-containing analogue Journal of Organic Chemistry, 74 (1). pp. 401-404. ISSN 0022-3263

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Official URL: http://pubs.acs.org/doi/abs/10.1021/jo8020264

Related URL: http://dx.doi.org/10.1021/jo8020264

Abstract

An efficient and practical total synthesis of marine cyclic tetrapeptide, natural product azumamide E (1) is achieved via high-yielding reactions. The strategy also allowed us to synthesize the azumamide E-SAA (sugar amino acid) analogue (2), whose solution-phase NMR and biological activity studies were also carried out.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:62349
Deposited On:22 Sep 2011 03:35
Last Modified:22 Sep 2011 03:35

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