Viault, Guillaume ; Grée, Danielle ; Roisnel, Thierry ; Chandrasekhar, Srivari ; Grée, René (2009) The first synthesis of 2-amino-1, 4-dihydroquinolines Tetrahedron, 65 (49). pp. 10149-10154. ISSN 0040-4020
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.tet.2009.10.018
Abstract
A versatile strategy is described for the synthesis of new 2-amino-1,4-dihydroquinolines. It involved a Knoevenagel condensation of N-protected-2-amino-5-bromobenzaldehyde with ethylcyanoacetate, followed by a cyclization and protection of the NH group to afford the key intermediates 7 or 19. Then various 1,4 addition reactions have been performed to introduce substituents on the upper part of the 2-amino-1,4-dihydroquinolines.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | 1,4-Dihydroquinolines; HA 14-1; Benzopyran; Anti-cancer; Bcl-2 |
| ID Code: | 62336 |
| Deposited On: | 22 Sep 2011 03:37 |
| Last Modified: | 22 Sep 2011 03:37 |
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