Novel helical foldamers: organized heterogeneous backbone folding in 1: 1 α /nucleoside-derived-β-amino acid sequences

Chandrasekhar, Srivari ; Kiranmai, Nayani ; Udaya Kiran, Marelli ; Sharada Devi, Ambure ; Pavan Kumar Reddy, Gangireddy ; Idris, Mohammed ; Jagadeesh, Bharatam (2010) Novel helical foldamers: organized heterogeneous backbone folding in 1: 1 α /nucleoside-derived-β-amino acid sequences Chemical Communications, 46 (37). pp. 6962-6964. ISSN 1359-7345

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Official URL: http://pubs.rsc.org/en/Content/ArticleLanding/2010...

Related URL: http://dx.doi.org/10.1039/C0CC01724H

Abstract

Secondary structural conformation of hybrid oligo-peptides comprised of 1:1 alternating Nucleoside Derived β -Amino acid (NDA) and L-amino acid residues has been reported. The studies reveal that the NDA residues organize the heterogeneous backbone featuring the surface properties of both nucleic acids and peptides, to adopt a novel 11/8-helical fold.

Item Type:Article
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Deposited On:22 Sep 2011 03:37
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