Pothukuchy, Arti ; Ellapan, Sampathkumar ; Gopidas, Karickal R. ; Salazar, Miguel (2003) Photo-oxidation of duplex DNA with the stable trioxatriangulenium ion Bioorganic & Medicinal Chemistry Letters, 13 (8). pp. 1491-1494. ISSN 0960-894X
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/S0960-894X(03)00121-5
Abstract
We show that 5'-Gs in 5'-GG-3' duplex DNA dinucleotide steps are preferentially oxidized by the trioxatriangulenium ion (TOTA⊕ ) upon photo-activation, an oxidation pattern characteristic of guanine radical cation formation. Some photo-oxidation of the 3'G in 5'GG3' steps and of isolated guanines is also observed but reactions carried out in D2O reveal only a minor increase in oxidation damage at these sites, indicating that electron transfer is the primary mechanism of guanine oxidation.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 62070 |
| Deposited On: | 16 Sep 2011 04:08 |
| Last Modified: | 16 Sep 2011 04:08 |
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