Panicker, Harsha ; Wadhwa, Shashi ; Roy, Tara S. (2002) Effect of prenatal sound stimulation on medio-rostral neostriatum/hyperstriatum ventrale region of chick forebrain: a morphometric and immunohistochemical study Journal of Chemical Neuroanatomy, 24 (2). pp. 127-135. ISSN 0891-0618
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/S0891-0618(02)00041-8
Abstract
The higher auditory association area in chick forebrain, i.e. medio-rostral neostriatum/hyperstriatum ventrale region (MNH), is involved in juvenile auditory filial imprinting. Studies show that neuronal size as well as expression of calcium-binding proteins, parvalbumin (PV) and calbindin D28K (CaBP) are regulated by neuronal activation. In the present study, we have determined the effect of extra auditory stimulation, given as a prenatal sound enrichment protocol, on MNH neurons of posthatch day 1 chicks. Patterned species-specific or musical (sitar) sounds were provided in a graded manner from embryonic day 10 through hatching. Thionin and immunohistochemically stained (PV and CaBP) neurons were evaluated by morphometric methods. The thionin-stained MNH neurons of both the auditory stimulated groups showed a significant increase in nuclear area compared to controls. The change in nuclear dimension was greater in the music-stimulated than in the species-specific sounds-stimulated group. These observations indicate a positive influence of prenatal sound stimulation on MNH neurons. The auditory stimulated groups also demonstrated an increase in the proportion of PV- and CaBP-neurons compared to controls, with the species-specific sounds-stimulated group showing a significantly higher percentage of immunostained cells than the music-stimulated group. However, immunostained cells of both the auditory stimulated groups did not show a significant change in size. These cytoplasmic proteins, by acting as intracellular buffers, enable neurons to display high electrical activity without calcium overload. The influx of Ca2+ ions is essential for long-term potentiation, a phenomenon important for learning and memory. The increase in percentage of the neurons containing calcium-binding proteins may provide a morphological basis for enhancement of auditory imprinting and learning.
Item Type: | Article |
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Source: | Copyright of this article belongs to Elsevier Science. |
Keywords: | Prenatal Auditory Enrichment; Chick; Calcium-Binding Proteins; Morphometry |
ID Code: | 61558 |
Deposited On: | 15 Sep 2011 12:49 |
Last Modified: | 15 Sep 2011 12:49 |
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