Dhar, Shanta ; Chakravarty, Akhil R. (2003) Efficient visible light induced nuclease activity of a ternary mono-1,10-phenanthroline copper(II) complex containing 2-(methylthio)ethylsalicylaldimine Inorganic Chemistry, 42 (8). pp. 2483-2485. ISSN 0020-1669
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Official URL: http://pubs.acs.org/doi/abs/10.1021/ic026241k
Related URL: http://dx.doi.org/10.1021/ic026241k
Abstract
Ternary Schiff base copper(II) complex [CuL(phen)](ClO4), where HL is 2-(methylthio)ethylsalicylaldimine and phen is 1,10-phenanthroline, has been prepared and structurally characterized by X-ray crystallography. The complex shows a CuN3OS coordination in a square-pyramidal (4 + 1) geometry with the sulfur as an equatorial ligand. The complex is an avid binder to double-stranded DNA in the minor groove and exhibits both photonuclease and chemical nuclease activity. When exposed to UV light of 312 nm (96 W) or visible light of 532 nm (125 W) under aerobic conditions, the complex causes significant cleavage of supercoiled pUC19 DNA in the absence of any externally added reducing agent or H2O2.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 6131 |
| Deposited On: | 19 Oct 2010 11:00 |
| Last Modified: | 27 May 2011 05:02 |
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