Jadi, R. S. ; Sudeep, A. B. ; Barde, P. V. ; Arankalle, V. A. ; Mishra, A. C. (2011) Development of an inactivated candidate vaccine against Chandipura virus (Rhabdoviridae: Vesiculovirus) Vaccine, 29 (28). pp. 4613-4617. ISSN 0264-410X
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.vaccine.2011.04.063
Abstract
A Vero cell based vaccine candidate against Chandipura (CHP) virus (Rhabdoviridae: Vesiculovirus), was developed and evaluated for immunogenicity in mice. Virus was purified by ultracentrifugation on 30% glycerol cushion followed by differential centrifugation on 10-60% sucrose gradient and inactivated with β-propio lactone at a concentration of 1:3500. The inactivated product was blended with aluminium phosphate (3%) and immunized 4-week-old Swiss albino mice. Neutralizing antibodies in the range of 1:10 to 160 and 1:80 to 1:320 was detected with 85% and 100% sero-conversion after 2nd and 3rd dose, respectively. All the immunized mice with antibody titer above 1:20 survived live virus challenge. The vaccine candidate has potential to be an efficient vaccine against CHP virus.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Chandipura Virus; Candidate Vaccine; Virus Encephalitis |
| ID Code: | 59810 |
| Deposited On: | 07 Sep 2011 14:45 |
| Last Modified: | 16 Jul 2012 15:15 |
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