Gurav, Yogesh K. ; Tandale, Babasaheb V. ; Jadi, Ramesh S. ; Gunjikar, Rashmi S. ; Tikute, Sanjaykumar S. ; Jamgaonkar, Aniruddha V. ; Khadse, Ravindra K. ; Jalgaonkar, Suresh V. ; Arankalle, Vidya A. ; Mishra, Akhilesh C. (2010) Chandipura virus encephalitis outbreak among children in Nagpur division, Maharashtra, 2007 Indian Journal of Medical Research, 132 . pp. 395-399. ISSN 0019-5340
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Abstract
Background & objectives: An outbreak of acute encephalitis syndrome (AES) among children from Nagpur division, Maharashtra was investigated to confirm the aetiology and to describe clinico-epidemiological features. Methods: AES cases among children < 15 yr, from Nagpur division, hospitalized between June-September 2007, were investigated. Serum and cerebrospinal fluid (CSF) were tested for IgM antibodies against Chandipura virus (CHPV) and Japanese encephalitis virus (JEV) and for CHPV RNA by RT-PCR. Partial N gene sequences were used for phylogenetic analysis. Virus isolations were attempted in rhabdomyosarcoma (RD) cell line. Sandflies were collected, pooled and tested for CHPV RNA by RT-PCR. Results: A total of 78 AES cases were recorded in children < 15 yr of age. Case fatality ratio was 43.6 per cent. Male to female ratio was 1:1.2. Chandipura (CHP) was confirmed in 39 cases. CHPV RNA was detected in both CSF and serum specimens of 2 cases and in serum of 22 cases. Phylogenetic analysis showed 99.98-100 per cent nucleotide identity in the sequences studied. Anti-CHPV IgM antibodies were detected in CSF of 2 cases and in serum of 8 cases. Seroconversion to anti-CHPV IgM antibodies was observed in 5 cases. Clinical manifestations of CHP cases (n=38) were fever (100%), convulsion (76.3%), altered sensorium (34.2%), headache (23.7%), vomiting (44.7%) and diarrhoea (23.7%). CHPV RNA was detected in one of two pools of sandflies from affected locality. Interpretation & conclusions: Chandipura virus was confirmed as the aetiological agent of this acute encephalitis outbreak with high case-fatality among children.
Item Type: | Article |
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Source: | Copyright of this article belongs to Indian Council of Medical Research. |
Keywords: | Acute Encephalitis Syndrome; Chandipura Virus; Children; Outbreak; Sandfly |
ID Code: | 59803 |
Deposited On: | 07 Sep 2011 14:45 |
Last Modified: | 18 May 2016 10:14 |
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