Emerson, Suzanne U. ; Clemente-Casares, Pilar ; Moiduddin, Nasser ; Arankalle, Vidya A. ; Torian, Udana ; Purcell, Robert H. (2006) Putative neutralization epitopes and broad cross-genotype neutralization of Hepatitis E virus confirmed by a quantitative cell-culture assay Journal of General Virology, 87 (3). pp. 697-704. ISSN 0022-1317
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Official URL: http://vir.sgmjournals.org/content/87/3/697.short
Related URL: http://dx.doi.org/10.1099/vir.0.81545-0
Abstract
Monolayers of Hep G2/C3A cells were inoculated with genotype 1 Hepatitis E virus (HEV) mixed with either anti-HEV or an appropriate control. After 5 or 6 days, cell monolayers were stained with anti-HEV and infected cells were identified by immunofluorescence microscopy and counted. Anti-HEV from vaccinated or infected rhesus monkeys neutralized the virus, as did mAbs that recognized epitopes on the C terminus of a recombinant vaccine protein. Antibodies were broadly cross-reactive, since convalescent serum from animals infected with any one of the four mammalian genotypes all neutralized the genotype 1 virus.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Society for General Microbiology. |
| ID Code: | 59750 |
| Deposited On: | 07 Sep 2011 14:39 |
| Last Modified: | 07 Sep 2011 14:39 |
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