Hepatitis E virus: can it be transmitted parenterally?

Arankalle, V. A. ; Chobe, L. P. (1999) Hepatitis E virus: can it be transmitted parenterally? Journal of Viral Hepatitis, 6 (2). pp. 161-164. ISSN 1352-0504

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Official URL: http://onlinelibrary.wiley.com/doi/10.1046/j.1365-...

Related URL: http://dx.doi.org/10.1046/j.1365-2893.1999.00141.x


Of 200 voluntary blood donors screened for hepatitis E virus (HEV) RNA, employing the reverse transcription-polymerase chain reaction (RT-PCR), three were found to be positive (1.5%). None of the HEV RNA-positive blood donors had any symptoms at the time of blood donation or during subsequent follow-up. One donor was positive for immunoglobulinM (IgM) antibodies to HEV, with a raised serum alanine aminotransferase (ALT) level, whereas the other two donors were negative for both immunoglobulinG (IgG) and IgM antibodies to HEV. Follow-up blood samples collected 2-5months later from HEV RNA-positive blood donors demonstrated the presence of IgG anti-HEV antibodies. Overall seroprevalence of IgG anti-HEV was 18.6%. Retrospective studies on samples collected from commercial blood donors and haemophiliacs revealed IgG anti-HEV positivity to be 24.6% (46/191) and 24.4% (22/90) and statistically not different (P > 0.1) from the prevalence among voluntary blood donors and an age-matched normal population, respectively. However, a highly significant proportion of the paid plasma donors, with a high prevalence of IgG antibodies to human immunodeficiency virus and hepatitis C virus, were positive for IgG antibodies to HEV (54/71, 76%, P < 0.001), indicating a possible role of blood-derived HEV in the transmission of the virus among plasma donors. These results demonstrate the possible risk of transfusion-associated hepatitis E in hyperendemic areas.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
Keywords:Blood Donors; HEV RNA; Parenteral Transmission
ID Code:59746
Deposited On:07 Sep 2011 14:34
Last Modified:07 Sep 2011 14:34

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