Kamal, Ahmed ; Srinivasa Reddy, K. ; Kaleem Ahmed, S. ; Khan, M. Naseer A. ; Sinha, Rakesh K. ; Yadav, J. S. ; Arora, Sudershan K. (2006) Anti-tubercular agents. Part 3. Benzothiadiazine as a novel scaffold for anti-Mycobacterium activity Bioorganic & Medicinal Chemistry, 14 (3). pp. 650-658. ISSN 0968-0896
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.bmc.2005.08.063
Abstract
In an effort to develop new and more effective therapies to treat tuberculosis, a series of benzothiadiazine 1,1-dioxide derivatives were synthesized and their in vitro activity against Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium intracellulare was evaluated. One of the compounds, 8c, exhibited potent anti-tubercular activity, particularly for the resistant strains and thus prompted us to investigate its in vivo profile. However, the in vivo testing in a mouse model of tuberculosis infection did not show significant anti-tubercular activity, probably because of its poor bioavailability.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 59573 |
| Deposited On: | 07 Sep 2011 05:42 |
| Last Modified: | 07 Sep 2011 05:42 |
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