Application of the Cosford cross-coupling protocol for the stereoselective synthesis of (R)-(+)-goniothalamin, (R)-(+)-kavain and (S)-(+)-7,8-dihydrokavain

Sabitha, Gowravaram ; Sudhakar, K. ; Yadav, J. S. (2006) Application of the Cosford cross-coupling protocol for the stereoselective synthesis of (R)-(+)-goniothalamin, (R)-(+)-kavain and (S)-(+)-7,8-dihydrokavain Tetrahedron Letters, 47 (48). pp. 8599-8602. ISSN 0040-4039

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.tetlet.2006.09.122

Abstract

An efficient and versatile synthetic method has been developed and utilized for the stereoselective synthesis of (R)-(+)-goniothalamin 1, (R)-(+)-kavain 2 and (S)-(+)-7,8-dihydrokavain 3. Application of the Cosford protocol and direct conversion of aldehydes to β-keto-esters are the key steps in our approach.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:6-substituted Lactones; Cosford Protocol; Natural Products; Acetylenic Alcohol
ID Code:58887
Deposited On:02 Sep 2011 03:24
Last Modified:02 Sep 2011 03:24

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