Yadav, J. S. ; Nanda, S. (2001) Novel chiral lipoxygenase substrates: design and synthesis. Part 2 Tetrahedron: Asymmetry, 12 (23). pp. 3223-3234. ISSN 0957-4166
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/S0957-4166(02)00009-5
Abstract
A series of novel lipoxygenase substrates carrying a spacing modifier with a non-ionic hydroxyl terminus have been synthesized in an enantioselective fashion. One of the methylene hydrogens (flanked by the cis,cis-pentadienyl moiety) is replaced by alkyl, aryl and hydroxyl groups. The key steps in the synthesis involved enzymatic transesterification of 1,3-propanediol derivatives and two consecutive cis-selective Wittig olefinations.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 58843 |
| Deposited On: | 02 Sep 2011 03:11 |
| Last Modified: | 02 Sep 2011 03:11 |
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