Sabitha, Gowravaram ; Raj Kumar, M. ; Shashi Kumar Reddy, M. ; Yadav, J. S. ; Rama Krishna, K. V. S. ; Kunwar, A. C. (2005) A D,L-proline catalyzed diastereoselective trimolecular condensation: an approach to the one-pot synthesis of perhydrofuro[3,2-b]pyran-5-ones Tetrahedron Letters, 46 (10). pp. 1659-1661. ISSN 0040-4039
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.tetlet.2005.01.071
Abstract
D,L-Proline was found to catalyze efficiently the one-pot trimolecular condensation of indoles, a sugar hydroxyaldehyde, and Meldrum's acid followed by intramolecular cyclization with evolution of carbon dioxide and elimination of acetone to afford 7-(1H-3-indolyl)-2,3-dimethoxyperhydrofuro[3,2-b]pyran-5-ones. The reaction proceeded cleanly at ambient temperature to afford the products in good yields with high diastereoselectivity.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | D,L-proline; Furo-pyranone; Indole; Trimolecular Condensation |
| ID Code: | 58826 |
| Deposited On: | 02 Sep 2011 03:21 |
| Last Modified: | 02 Sep 2011 03:21 |
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