Yadav, J. S. ; Deshpande, Prasad K. ; Sharma, G. V. M. (1990) An effective practical method for the synthesis of chiral propargyl alcohols Tetrahedron, 46 (20). pp. 7033-7046. ISSN 0040-4020
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/S0040-4020(01)87888-1
Abstract
The preparation of chiral propargyl alcohols (2) is described by LiNH2 or LDA induced double elimination of chiral epoxychlorides (4) derived from their corresponding epoxyalcohols (3) which are available easily by Sharpless asymmetric epoxidation of the primary allyl alcohols. Whereas use of stoichiometiric amount of base on 4 provides chirally enriched trans-1-chlorovinyl alcohols (14).
Item Type: | Article |
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ID Code: | 58743 |
Deposited On: | 02 Sep 2011 03:08 |
Last Modified: | 02 Sep 2011 03:08 |
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