Rajasekar, Reena ; Mathews, Vikram ; Lakshmi, Kavitha M. ; Sellathamby, Shanmugaapriya ; George, Biju ; Viswabandya, Auro ; Daniel, Dolly ; Chandy, Mammen ; Srivastava, Alok (2008) Plasmacytoid dendritic cell count on day 28 in HLA-matched related allogeneic peripheral blood stem cell transplant predicts the incidence of acute and chronic GVHD Biology of Blood and Marrow Transplantation, 14 (3). pp. 344-350. ISSN 1083-8791
![]()
|
PDF
- Publisher Version
255kB |
Official URL: http://www.bbmt.org/article/S1083-8791(08)00006-2/...
Related URL: http://dx.doi.org/10.1016/j.bbmt.2007.12.494
Abstract
Dendritic cells (DC) are antigen-presenting cells involved in induction and regulation of immune responses. We investigated the impact of the number of infused and day 28 dendritic cells on the development of acute and chronic GVHD (aGVHD, cGVHD). Monocytoid (MC) and plasmacytoid (PC) dendritic cells were characterized as lin-HLA-DR+CD11c+ and lin-HLA-DR+CD123+, respectively. Sixty-eight consecutive patients who underwent HLA matched related granuloyte-colony stimulating factor (G-CSF) mobilized allogeneic PBSCT, from February 2005 to May 2006, were included in the analysis. Twenty-three patients developed aGVHD (grade II-IV) and 21 patients had cGVHD. On a univariate analysis the day 28 total DC and the day 28 MC and PC dendritic cells as continuous variables were significantly associated with development of aGVHD and cGVHD. Using an ROC plot analysis a cutoff value for total DC = 10.7/μL, MC = 9.7/μL, and PC = 4.5/μL on day 28 gave the highest likelihood ratios for aGVHD (2.7, 2.14, and 3.29, respectively). On a multivariate analysis, a low day 28 PC (≤4.5/μL) together with patient age retained their risk for aGVHD (hazard ratio [HR] = 65.1 and 1.0, P-values .000 and .036, respectively), whereas for cGVHD only a low day 28 PC remained significant (HR = 11.8, P = .008). These results suggest that the PC dendritic cell count in the peripheral blood on day 28 is a strong predictor for development of GVHD in recipients of an allogeneic matched related PBSCT.
Item Type: | Article |
---|---|
Source: | Copyright of this article belongs to American Society for Blood and Marrow Transplantation. |
Keywords: | Acute GVHD; Chronic GVHD; Plasmacytoid Dendritic Cell Count; GVHD Prediction; PBSCT |
ID Code: | 5873 |
Deposited On: | 19 Oct 2010 10:24 |
Last Modified: | 16 May 2016 16:19 |
Repository Staff Only: item control page