Intramolecular ketonitrone-olefin cycloaddition reaction: direct and stereocontrolled synthesis of nitrogenated quaternary centered aminocyclopentitols as galactosidase inhibitors

Suman Reddy, Y. ; Kadigachalam, P. ; Doddi, Venkata Ramana ; Vankar, Yashwant D. (2009) Intramolecular ketonitrone-olefin cycloaddition reaction: direct and stereocontrolled synthesis of nitrogenated quaternary centered aminocyclopentitols as galactosidase inhibitors Tetrahedron Letters, 50 (42). pp. 5827-5830. ISSN 0040-4039

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.tetlet.2009.07.157

Abstract

Synthesis of nitrogenated quaternary centered polyhydroxylated aminocyclopentanes by implementation of ketonitrone-olefin cycloaddition reaction as a key step has been accomplished in a stereocontrolled manner. The target molecules were found to be moderate but selective inhibitors of galactosidases.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Ketonitrone; Cycloaddition; Aminocyclopentitol; Glycosidase Inhibitors
ID Code:58296
Deposited On:31 Aug 2011 06:41
Last Modified:31 Aug 2011 06:41

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