(3S,4R,5R)-3-(2-Hydroxyethyl)piperidine-3,4,5-triol as an isofagomine analogue: synthesis and glycosidase inhibition study

Gupta, Preeti ; Dharuman, Suresh ; Vankar, Yashwant D. (2010) (3S,4R,5R)-3-(2-Hydroxyethyl)piperidine-3,4,5-triol as an isofagomine analogue: synthesis and glycosidase inhibition study Tetrahedron: Asymmetry, 21 (24). pp. 2966-2972. ISSN 0957-4166

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.tetasy.2010.11.027

Abstract

The synthesis of (3S,4R,5R)-3-(2-hydroxyethyl)piperidine-3,4,5-triol 10 has been described from D-glucose. The base promoted cyclization for the construction of the piperdine framework is the key step of the synthesis.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:58286
Deposited On:31 Aug 2011 06:42
Last Modified:31 Aug 2011 06:42

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