Yadav, Veejendra K. ; Senthil, Govindaraji ; Singh, Latika ; Parvez, Masood (2004) On the reaction of 1-oxa-4-thiaspiro [4.5] decan-7-one with PhLi. A reinvestigation Journal of Organic Chemistry, 69 (23). pp. 8131-8132. ISSN 0022-3263
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Official URL: http://pubs.acs.org/doi/abs/10.1021/jo0489364
Related URL: http://dx.doi.org/10.1021/jo0489364
Abstract
Two diastereomeric alcohols are formed from the reaction of 1-oxa-4-thiaspiro[4.5]decan-7-one with PhLi as against the single diastereomer reported earlier. The diastereoselectivity achieved from PhMgBr is significantly higher than with PhLi. The use of Et2O/hexane=2:1 as the solvent for the reaction with PhMgBr offered the highest (14:1) diastereocontrol.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 58247 |
| Deposited On: | 31 Aug 2011 06:56 |
| Last Modified: | 31 Aug 2011 06:56 |
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