Yadav, Veejendra K. ; Balamurugan, Rengarajan (2003) Diastereoselective aldol reactions of enolates generated from vicinally substituted trimethylsilylmethyl cyclopropyl ketones Organic Letters, 5 (23). pp. 4281-4284. ISSN 1523-7060
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Official URL: http://pubs.acs.org/doi/abs/10.1021/ol035481g
Related URL: http://dx.doi.org/10.1021/ol035481g
Abstract
Vicinally substituted trimethylsilylmethyl cyclopropyl ketones undergo facile desilylative ring opening with Lewis acids under mild conditions. The enolates, thus generated, undergo aldol addition with aldehydes and ketones. The diastereoselectivity of the reaction with aldehydes depends on the nature of the Lewis acid used. The resulting aldol product is easily converted into a substituted tetrahydrofuran derivative.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 58219 |
| Deposited On: | 31 Aug 2011 06:55 |
| Last Modified: | 31 Aug 2011 06:55 |
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