Rawal, Girish K. ; Kumar, Amit ; Tawar, Urmila ; Vankar, Yashwant D. (2007) New method for chloroamidation of olefins. Application in the synthesis of N-glycopeptides and anticancer agents Organic Letters, 9 (25). pp. 5171-5174. ISSN 1523-7060
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Official URL: http://pubs.acs.org/doi/abs/10.1021/ol702097q
Related URL: http://dx.doi.org/10.1021/ol702097q
Abstract
Chloroamidation of olefins using a new reagent system (COCl)2-AgNO3-CH3CN was observed. Various glycals with this reagent system produce 2-chloro-1-acetamido sugars in good yields which, in turn, were converted to free amino derivatives and various glycopeptides. The acetamido sugar derivatives and free amines were found to be promising anticancer agents against the U-87 malignant glyoma (a brain tumor) cell line with IC-50=1 nm-22 μM, and they were found to be far less cytotoxic against a normal human embryonic kidney cell line.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 58171 |
| Deposited On: | 31 Aug 2011 06:40 |
| Last Modified: | 31 Aug 2011 06:40 |
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