John Pal, A. P. ; Gupta, Preeti ; Suman Reddy, Y. ; Vankar, Yashwant D. (2010) Synthesis of fused oxa-aza spiro sugars from D-glucose-derived δ-lactone as glycosidase inhibitors European Journal of Organic Chemistry, 2010 (36). pp. 6957-6966. ISSN 1434-193X
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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/ejoc.20...
Related URL: http://dx.doi.org/10.1002/ejoc.201001102
Abstract
Four conformationally constrained fused oxa-aza spiro sugars have been synthesized from perbenzylated D-gluconolactone involving C-glycosylation of ketoses by using Me3SiCN, ring-closing metathesis, and diastereoselective dihydroxylation as key steps. Two of the four spiro sugars were found to be highly selective but moderate inhibitors of α-mannosidase.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons. |
| Keywords: | Glycosylation; Metathesis; Dihydroxylation; Spiro Compounds; Azasugars; Enzyme Inhibitors |
| ID Code: | 58168 |
| Deposited On: | 31 Aug 2011 06:42 |
| Last Modified: | 31 Aug 2011 06:42 |
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