Synthesis of pyrrolidine-based imino sugars as glycosidase inhibitors

Doddi, Venkata Ramana ; Vankar, Yashwant D. (2007) Synthesis of pyrrolidine-based imino sugars as glycosidase inhibitors European Journal of Organic Chemistry, 2007 (33). pp. 5583-5589. ISSN 1434-193X

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/ejoc.20...

Related URL: http://dx.doi.org/10.1002/ejoc.200700719

Abstract

Two pyrrolidine-based imino sugars have been synthesized in an efficient manner, using regiospecific amination, ring closing metathesis, and diastereospecific dihydroxylations as key steps. These azasugars are found to be moderate inhibitors of glycosidases.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
Keywords:Regiospecific Amination; Ring Closing Metathesis; Diastereospecific Dihydroxylation
ID Code:58166
Deposited On:31 Aug 2011 06:39
Last Modified:31 Aug 2011 06:39

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