Synthesis of hybrids of D-glucose and D-galactose with pyrrolidine-based iminosugars as glycosidase inhibitors

Doddi, Venkata Ramana ; Kokatla, Hari Prasad ; John Pal, A. P. ; Basak, Ranjan K. ; Vankar, Yashwant D. (2008) Synthesis of hybrids of D-glucose and D-galactose with pyrrolidine-based iminosugars as glycosidase inhibitors European Journal of Organic Chemistry, 2008 (34). pp. 5731-5739. ISSN 1434-193X

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/ejoc.20...

Related URL: http://dx.doi.org/10.1002/ejoc.200800770

Abstract

Sugar-iminosugar hybrid molecules made up of D-glucose and D-galactose with pyrrolidine-based iminosugars, viz. 1,4-dideoxy-1,4-imino-L-xylitol and 1,4-dideoxy-1,4-imino-L-lyxitol, are synthesized from glycal epoxides and found to be moderate glycosidase inhibitors.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
Keywords:Glycosidase Inhibitors; Iminosugars; Azasugars; Oxidative Cyclization
ID Code:58164
Deposited On:31 Aug 2011 06:41
Last Modified:31 Aug 2011 06:41

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