Concentration-independent spontaneously forming biomimetric vesicles

Nieh, M.-P. ; Harroun, T. A. ; Raghunathan, V. A. ; Glinka, C. J. ; Katsaras, J. (2003) Concentration-independent spontaneously forming biomimetric vesicles Physical Review Letters, 91 (15). 158105_1-158105_4. ISSN 0031-9007

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Official URL: http://prl.aps.org/abstract/PRL/v91/i15/e158105

Related URL: http://dx.doi.org/10.1103/PhysRevLett.91.158105

Abstract

In this Letter we present small-angle neutron scattering data from a biomimetic system composed of the phospholipids dimyristoyl and dihexanoyl phosphorylcholine (DMPC and DHPC, respectively). Doping DMPC-DHPC multilamellar vesicles with either the negatively charged lipid dimyristoyl phosphorylglycerol (DMPG, net charge -1) or the divalent cation, calcium (Ca2+), leads to the spontaneous formation of energetically stabilized monodisperse unilamellar vesicles whose radii are concentration independent and in contrast with previous experimental observations.

Item Type:Article
Source:Copyright of this article belongs to The American Physical Society.
ID Code:57502
Deposited On:27 Aug 2011 12:26
Last Modified:18 May 2016 08:52

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