Harroun, T. A. ; Nieh, M.-P. ; Watson, M. J. ; Raghunathan, V. A. ; Pabst, G. ; Morrow, M. R. ; Katsaras, J. (2004) Relationship between the unbinding and main transition temperatures of phospholipid bilayers under pressure Physical Review E - Statistical, Nonlinear and Soft Matter Physics, 69 (3). 031906_1-031906_8. ISSN 1539-3755
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Official URL: http://pre.aps.org/abstract/PRE/v69/i3/e031906
Related URL: http://dx.doi.org/10.1103/PhysRevE.69.031906
Abstract
Using neutron diffraction and a specially constructed high pressure cell suitable for aligned multibilayer systems, we have studied, as a function of pressure, the much observed anomalous swelling regime in dimyristoyl- and dilauroyl-phosphatidylcholine bilayers, DMPC and DLPC, respectively. We have also reanalyzed data from a number of previously published experiments and have arrived at the following conclusions. (a) The power law behavior describing anomalous swelling is preserved in all PC bilayers up to a hydrostatic pressure of 240 MPa. (b) As a function of increasing pressure there is a concomitant decrease in the anomalous swelling of DMPC bilayers. (c) For PC lipids with hydrocarbon chains ≥13 carbons the theoretical unbinding transition temperature T* is coupled to the main gel-to-liquid crystalline transition temperature TM. (d) DLPC is intrinsically different from the other lipids studied in that its T* is not coupled to TM. (e) For DLPC bilayers we predict a hydrostatic pressure (>290MPa) where unbinding may occur.
Item Type: | Article |
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Source: | Copyright of this article belongs to The American Physical Society. |
ID Code: | 57501 |
Deposited On: | 27 Aug 2011 12:26 |
Last Modified: | 18 May 2016 08:52 |
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