Sathyapriya, R. ; Brinda, K. V. ; Vishveshwara, Saraswathi (2006) Correlation of the side-chain hubs with the functional residues in DNA binding protein structures Journal of Chemical Information and Modeling, 46 (1). pp. 123-129. ISSN 1549-9596
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Official URL: http://pubs.acs.org/doi/abs/10.1021/ci050122g
Related URL: http://dx.doi.org/10.1021/ci050122g
Abstract
The structure networks of DNA-binding proteins have been constructed and analyzed. The detailed analysis of the networks indicates a strong relation between the positions of the residues interacting with DNA and those that form extensive interactions within the protein structure (called hubs). This study shows that the functional residues in these proteins are held in place by efficient scaffolding of the structure using side-chain interactions, thus highlighting the role of these side-chain hubs with respect to the functional residues in the protein structure.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 57075 |
| Deposited On: | 26 Aug 2011 02:43 |
| Last Modified: | 26 Aug 2011 02:43 |
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