Geiner, S. ; Horn, A. K. E. ; Wadia, N. H. ; Sakai, H. ; Buttner-Ennever, J. A. (2008) The neuroanatomical basis of slow saccades in spinocerebellar ataxia type 2 (Wadia-subtype) Progress in Brain Research, 171 . pp. 575-581. ISSN 0079-6123
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/S0079-6123(08)00683-3
Abstract
In a case of spinocerebellar ataxia type 2, Wadia-subtype (SCA2), with slow horizontal saccades, we used parvalbumin immunohistochemistry to identify the omnipause (OPNs) excitatory (EBNs), and inhibitory burst neurons (IBNs) of the saccade generator. Nissl sections was used to measure neuronal diameters, and synaptophysin staining to estimate of synaptic density on the cell somata. Morphometric and synaptic density measurements of the abducens motoneurons were identical in SCA2 and the control. A significant cell loss and reduced synaptic density on somata was found only in the EBN area. We conclude that degeneration of the EBNs is the most likely cause for the slowing of horizontal saccades.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Horizontal Excitatory Burst Neurons; Omnipause Neurons; Inhibitory Burst Neurons; Parvalbumin; Synaptic Density; Olivopontocerebellar Atrophy; Abducens Motoneurons |
| ID Code: | 56996 |
| Deposited On: | 25 Aug 2011 13:10 |
| Last Modified: | 25 Aug 2011 13:10 |
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