Bakre, Manjiri M. ; Visweswariah, Sandhya S. (1997) Dual regulation of heat-stable enterotoxin-mediated cGMP accumulation in T84 cells by receptor desensitization and increased phosphodiesterase activity FEBS Letters, 408 (3). pp. 345-349. ISSN 0014-5793
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/S0014-5793(97)00458-4
Abstract
We report the regulation of cGMP accumulation induced by the heat-stable enterotoxin, STh, in the T84 human colonic cell line. STh binding to its receptor, guanylyl cyclase C (GCC), leads to elevated intracellular levels of cGMP. Prolonged exposure of T84 cells to STh induced refractoriness to further cGMP accumulation, without significant receptor internalization, but with reduced STh-induced cGMP synthesis by the receptor. Significantly, increased degradation of cGMP by a cGMP-specific phosphodiesterase was observed in desensitized cells. This is the first report on the desensitization of GCC, as well as the role of the Type V phosphodiesterase in inducing cellular refractoriness.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Guanylyl Cyclase C; Heat-stable Enterotoxins; Cellular Refractoriness; cGMP-binding; cGMP-specific Phosphodiesterase |
| ID Code: | 56946 |
| Deposited On: | 25 Aug 2011 09:15 |
| Last Modified: | 25 Aug 2011 09:15 |
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