Chandy, M. ; Balasubramanian, P. ; Ramachandran, S. V. ; Mathews, V. ; George, B. ; Dennison, D. ; Krishnamoorthy, R. ; Srivastava, A. (2005) Randomized trial of two different conditioning regimens for bone marrow transplantation in thalassemia - the role of busulfan pharmacokinetics in determining outcome Bone Marrow Transplantation, 36 (10). pp. 839-845. ISSN 0268-3369
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Official URL: http://www.nature.com/bmt/journal/v36/n10/full/170...
Related URL: http://dx.doi.org/10.1038/sj.bmt.1705151
Abstract
In total, 94 patients with homozygous beta thalassemia were randomized to two different conditioning regimens: busulfan 600 mg/m2+cyclophosphamide 200 mg/kg or busulfan 16 mg/kg+cyclophosphamide 200 mg/kg and antilymphocyte globulin (47 in each group), for bone marrow transplantation, to see whether increased myeloablation or increased immunosuppression would reduce rejection. Busulfan pharmacokinetics in determining outcome was evaluated. There was no significant difference in engraftment, graft-versus-host disease, rejection, and overall and disease-free survival in the two groups. Systemic exposure to busulfan was significantly higher in the 600 mg/m2 group, but in both groups there was a wide interindividual variation in the busulfan kinetics. Six patients rejected the graft, two in the busulfan 600 mg group and four in busulfan 16 mg group (P=0.677 CI -0.17, 0.07), but in five patients (pharmacokinetic data not available in one patient) who rejected the graft busulfan first dose trough level (Cmin-1) was below 150 ng/ml while it was above this level in the 66 of 68 patients with successful engraftment (P0.001). This randomized trial shows that rejection is influenced by busulfan levels and suggests that monitoring of busulfan levels and dose adjustment based on first-dose kinetics may reduce the risk of rejection.
Item Type: | Article |
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Source: | Copyright of this article belongs to Nature Publishing Group. |
Keywords: | Busulfan; Pharmacokinetics; Thalassemia |
ID Code: | 5691 |
Deposited On: | 19 Oct 2010 11:30 |
Last Modified: | 16 May 2016 16:09 |
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