Dinda, Amit K. ; Kharbanda, Kusum ; Sarkar, Chitra ; Roy, Subimal ; Mathur, Meera ; Banerji, Ajit K. (1993) In-vivo proliferative potential of primary human brain tumors; its correlation with histological classification and morphological features: I gliomas Pathology, 25 (1). pp. 4-9. ISSN 0031-3025
Full text not available from this repository.
Official URL: http://informahealthcare.com/doi/abs/10.3109/00313...
Related URL: http://dx.doi.org/10.3109/00313029309068893
Abstract
This study was undertaken to investigate in-vivo proliferative potential of neoplastic cells in 66 cases of gliomas of different histological types following peroperative intravenous infusion of bromodeoxyuridine (BrdU). Histological typing according to the recent modification of WHO classification did not often correlate with in-vivo cell kinetics. Among the different morphological features used for the classification, necrosis, mitosis, increased cell density and increased endothelial cell proliferation showed good correlation with tumor cell labelling index (LI) (p < 0.01-p < 0.001). A preliminary follow-up study of 36 cases for a period ranging from 9 to 36 mths suggested the possibility that higher in-vivo tumor cell LI might be associated with an early recurrence. Thus in vivo BrdU LI may supplement the histological classification of gliomas and together they may help in a better assessment of their growth rate, degree of malignancy and biological behaviour which in turn facilitate the planning of therapeutic management for individual cases.
Item Type: | Article |
---|---|
Source: | Copyright of this article belongs to Informa plc. |
Keywords: | Gliomas; in-vivo Cell Kinetics; Bromodeoxyurdine; Histological Classification; Morphological Features |
ID Code: | 56405 |
Deposited On: | 24 Aug 2011 11:41 |
Last Modified: | 24 Aug 2011 11:41 |
Repository Staff Only: item control page