Ependymoma with extensive lipidization mimicking adipose tissue: a report of five cases

Sharma, Mehar Chand ; Arora, Rina ; Lakhtakia, Ritu ; Mahapatra, Ashok Kumar ; Sarkar, Chitra (2000) Ependymoma with extensive lipidization mimicking adipose tissue: a report of five cases Pathology & Oncology Research, 6 (2). pp. 136-140. ISSN 1219-4956

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Official URL: http://www.springerlink.com/content/43660g26468v15...

Related URL: http://dx.doi.org/10.1007/BF03032364

Abstract

Lipomatous ependymoma is a recently described entity and only 3 cases of this variant have been reported in the literature. We report 5 cases of this rare variant of ependymoma. Patients' age ranged from 4 years to 45 years and, interestingly, all of them were males. Two tumors were supratentorial in location, 2 in the fourth ventricle and 1 was intramedullary. Microscopically all of them showed the classical histology of ependymoma along with lipomatous differentiation. The lipomatous component was composed of cells with a large clear vacuole pushing the nucleus to the periphery and giving a signet ring cell appearance. This component demonstrated positivity for GFAP and S-100 protein thereby confirming its glial lineage. Three of the 5 tumors were high grade (WHO-grade III), had a high MIB-1 labelling index (MIB-1 LI) and showed recurrence on follow-up. However, 2 were low grade (WHO grade II) and patients are free of disease till the last follow up.

Item Type:Article
Source:Copyright of this article belongs to Arányi Lajos Foundation.
Keywords:Ependymoma; Adipocyte; Metaplasia; Lipomatous Change; Signet Ring Cell; Intracranial Tumor
ID Code:56312
Deposited On:23 Aug 2011 11:46
Last Modified:23 Aug 2011 11:46

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