Simultaneous alterations of retinoblastoma and p53 protein expression in astrocytic tumors

Rathore, Annapurna ; Kamarajan, Pacchapam ; Mathur, Meera ; Sinha, Subrata ; Sarkar, Chitra (1999) Simultaneous alterations of retinoblastoma and p53 protein expression in astrocytic tumors Pathology & Oncology Research, 5 (1). pp. 21-27. ISSN 1219-4956

Full text not available from this repository.

Official URL:

Related URL:


The genetic alterations frequently involved in glial malignancies are in the tumor suppressor genes, Rb and p53. An altered Rb expression or p53 overexpression is thought to indicate defective tumor suppression and subsequently more aggressive tumors. Therefore, to assess the alterations in the conjoint expression of Rb and p53 proteins in formalin fixed paraffin embedded sections, 64 astrocytic tumors were studied (16 astrocytomas, 7 gemistocytic astrocytomas, 19 anaplastic astrocytomas and 22 glioblastomas) using the avidin biotin immunoperoxidase technique. Fifty two cases (81.25%) were found to be positive for p53 protein. Seventeen of these showed aberrant heterogenous staining for pRb, of which 7 were glioblastomas. Only one case of astrocytoma showed aberrant expression of both p53 and Rb. Thus, of the 64 tumors, simultaneous aberrant expression of both p53 and Rb was seen in 21.9% of cases. This was more commonly observed among glioblastoma cases (7/22). No statistical difference was found between the survival rate of heterogenous pRb and p53 positivity in different grades of tumors. In glioblastomas, the survival rate appeared to be less in patients expressing heterogenous pRb, but this was not statistically significant. These results lead us to suspect that p53 and pRb pathways are inactivated, either through mutation or as part of the neoplastic process in astrocytic tumors.

Item Type:Article
Source:Copyright of this article belongs to Arányi Lajos Foundation.
Keywords:Astrocytic Tumors; p53; pRb; Immunochemistry; Survival
ID Code:56301
Deposited On:23 Aug 2011 11:45
Last Modified:15 Jul 2012 09:47

Repository Staff Only: item control page